TRETINOIN- AND 4-HYDROXYANISOLE-CONTAINING TOPICAL COMPOSITION STABLE IN STORAGE Russian patent published in 2006 - IPC A61K8/03 A61K8/33 A61K8/67 A61Q19/00 A61Q99/00 

FIELD: medicine, dermatology, pharmacy.

SUBSTANCE: invention proposes a topical solution for treatment of solar lentiginosis and hyperpigmentated injures showing prolonged stability in storage and comprising the following components: (a) from about 0.5 to about 5 wt.-%/vol. of 4-hydroxyanisole; (b) from about 0.002 to about 0.05 wt.-%/vol. of tretinoin; (c) from about 2 to about 10 vol./vol.% of liquid low-molecular polyethylene glycol; (d) from about 0.001 to about 1.5 wt.-%/vol. of antioxidant or mixture of antioxidants. Antioxidants or mixtures of antioxidants are taken so to provide at least two functions of oxygen absorption, free-radical chain rupture or reduction: (e) from about 0.001 to about 0.1 wt.-%/vol. of chelating agent; (f) from about 50 to about 88 vol./vol.% of lower alcanol; and (g) water, up to 100%. Proposed solution has pH value from about 2.5 to about 5 and water content at least 12 vol./vol.%. Invention provides enhancing stability of the solution.

EFFECT: improved and valuable properties of composition.

13 cl, 1 ex