FIELD: pharmacology.
SUBSTANCE: pharmaceutical composition for topical application is shown. It comprises of a therapeutically effective amount of active pharmaceutical ingredient (API) - a compound of the structural formula 
of at least one acidifying agent and a base carrier comprising of at least one pharmaceutically acceptable nonaqueous solvent. The acidifying agent is separated from citric acid, acetic acid and phosphoric acid. The measured pH value of the pharmaceutical composition is from 3 to 5. Preferably, the pharmaceutically acceptable nonaqueous solvent is a mixture of ethanol and propylene glycol. Also, a kit for preparing a pharmaceutical composition and a method for treating a proliferative, immune and skin diseases in a subject are desribed. The values of n, R1 and R2 in the structural formula (I) are defined in the claims.
EFFECT: stabilized pharmaceutical composition is obtained.
26 cl, 1 dwg, 18 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION FOR TOPICAL USE | 2018 |
|
RU2807884C2 |
| COMPOSITION FOR LOCAL APPLICATION CONTAINING TACROLIMUS | 2017 |
|
RU2741504C2 |
| COMPOSITIONS AND METHODS OF TREATING NAIL DISEASES | 2008 |
|
RU2519664C2 |
| ANTIPERSPIRANT COMPOSITIONS | 2015 |
|
RU2700412C2 |
| PHARMACEUTICAL COMPOSITIONS OF SPIRO-OXINDOLE COMPOUND FOR LOCAL ADMINISTRATION AND USE THEREOF AS THERAPEUTIC AGENTS | 2011 |
|
RU2596488C2 |
| LIQUID COMPOSITIONS OF RIFAXIMIN | 2020 |
|
RU2823287C1 |
| PIMECROLIMUS FOAMY COMPOSITION INCLUDING HEXYLENE GLYCOL, OPTIONALLY OLEYL ALKOHOL AND/OR MEDIUM CHAIN TRIGLYCERIDES | 2005 |
|
RU2375044C2 |
| COMPOSITION FOR TOPICAL USE | 2019 |
|
RU2806765C2 |
| TRANSDERMAL MEMANTINE DELIVERY SYSTEMS | 2017 |
|
RU2764764C2 |
| COMPOSITION FOR TOPICAL USE | 1995 |
|
RU2181592C2 |
