FIELD: medicine, polymers, virology, pharmacy.
SUBSTANCE: invention relates to new derivative of gossypol representing gossypol and carboxymethylcellulose copolymer sodium salt. Gossypol and carboxymethylcellolose copolymer sodium salt represents compound of the formula (I):
wherein a : b : c = 1:(3-6):(5-7), respectively, with molecular mass 120000-130000 Da and the replacing degree 0.35-0.80. Pharmaceutical preparation possessing with antiviral activity comprises gossypol and carboxymethylcellulose copolymer sodium salt of abovementioned formula and pharmaceutically acceptable carrier or excipient. Method for treatment of herpes infection involves administration the effective dose of abovementioned pharmaceutical preparation in the patient. Invention provides preparing compound possessing the enhanced solubility and diminished toxicity.
EFFECT: improved method for prophylaxis and treatment, valuable medicinal properties of copolymer.
5 cl, 3 tbl, 16 ex
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