METHOD FOR BROMINATION OF α- AND β-ERGOCRYPTINES Russian patent published in 2006 - IPC C07D457/00 C07D519/00 A61K31/48 

FIELD: chemical-pharmaceutical industry, chemical technology.

SUBSTANCE: invention relates to a method for preparing neurohormonal agent - abergin (α- and β-bromoergocryptines). Bromination of mixture of α- and β-ergocryptines is carried out with 50% excess of N-bromosuccinimide in chloroform medium with addition of dioxane (10:1). Method involves using dioxane with peroxide content in the amount 0.011-0.0145 mole part with respect to amount of alkaloids in the reaction medium wherein the parent concentration of ergotoxine alkaloids is 0.125-0.150 mole/l. Method provides enhancing yield of the end substance at the key stage of the bromination reaction.

EFFECT: improved preparing method.

1 tbl, 2 dwg, 1 ex