FIELD: chemistry.
SUBSTANCE: method of producing di(4-cyanophenyl)bromomethane can be used as an intermediate product in synthesis of medicinal agents, particularly anticancer drug letrozole. The disclosed method of producing di(4-cyanophenyl)bromomethane includes bromation of di(4-cyanophenyl)methane with bromosuccinimide in an inert solvent in the presence of benzoyl peroxide while heating. The reaction is carried out with an excess of 0.2-0.3 mol bromosuccinimide at 105-115°C.
EFFECT: method increases output and purity of the product.
2 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 1-[DI (4-CYANOPHENYL)METHYL]-1,2,4-TRIAZOLE | 2009 |
|
RU2425038C2 |
| METHOD OF SYNTHESIS OF 3-ALKOXYCARBONYL - 2 - METHYL - 2 - PROPENYLPHOSPHONIC ACID DIISOPROPYL ESTERS | 0 |
|
SU1810349A1 |
| 0 |
|
SU250144A1 | |
| METHOD OF OBTAININE PENTASACCHARIDE | 0 |
|
SU1694065A3 |
| METHOD OF OBTAINING HYDROCHLORIDE 2-PHENYLTHIOMETHYL-3- CARBOTOXY-4-DIMETHYLAMINOMETHYL-5-OXYBENZOFURAN | 1979 |
|
SU826707A1 |
| ENVIRONMENTALLY SAFE METHOD FOR PRODUCTION OF HIGH- PURITY TETRABROMOBISPHENOL A | 2001 |
|
RU2247105C2 |
| METHOD OF PRODUCING DERIVATIVES OF 4,4-DIFLUORO-3,4-DIHYDROISOQUINOLIN | 2012 |
|
RU2616608C2 |
| METHOD OF PRODUCING DI(4-CYANOPHENYL)METHANE | 2013 |
|
RU2527473C1 |
| METHOD FOR BROMINATION OF α- AND β-ERGOCRYPTINES | 2004 |
|
RU2274640C1 |
| METHOD OF SYNTHESIS OF 1-(2-CHLOROPHENYL)-DIPHENYL-1H-IMIDAZOLE | 2000 |
|
RU2171804C1 |
