ARYLATED AMIDES OF FURAN AND THIOPHENE CARBOXYLIC ACIDS WITH EFFECT INHIBITING POTASSIUM CHANNEL Russian patent published in 2006 - IPC C07D307/68 C07D333/38 A61K31/381 A61K31/341 A61P9/06 

Abstract RU 2275366 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to arylated amides of furan and thiophene carboxylic acids of the formulae (Ia) and (Ib) wherein W means oxygen or sulfur atom; R(1) means -C(O)OR(9) or -COR(11) wherein R(9) and R(11) mean independently of one another CxH2x-R(14) wherein x means 0, 1, 2 or 3; R(14) means phenyl, and to their pharmaceutically acceptable salts also. Also, invention describes a pharmaceutical composition and using proposed compounds a medicinal agents. Compounds can be used as anti-arrhythmic biologically active substances and especially in treatment and prophylaxis of atrium arrhythmia.

EFFECT: valuable medicinal properties of compounds and composition.

11 cl, 29 ex

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RU 2 275 366 C2

Authors

Pojkert Shtefan

Brendel' Joakhim

Khemmerle Khorst

Kleemann Khajnts-Verner

Dates

2006-04-27Published

2001-11-29Filed