BIS-ARYL COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND THEIR USING Russian patent published in 2006 - IPC C07D213/81 C07D213/82 A61K31/44 A61P9/06 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new bis-aryl compounds of the formula (I): wherein one among A1-A4 means nitrogen atom and others mean -CH or -CR5; A5-A8 mean -CH or -CR5; R5 means halogen atom or (C₁-C)-alkyl; R(1) means -C(O)OR(9), -COR(11); R(9) and R(11) mean C_xH_2x-R(14); x means 0, 1,2, 3 or 4 and x can't mean 0 if R(14) means -OR(15); R(14) means (C₁-C₆)-alkyl or phenyl; R(15) means (C₁-C₅)-alkyl; R(2) means hydrogen atom; R(3) means C_yH_2y-R(16) wherein y means 0, 1, 2, 3 or 4 and y can't mean 0 if R(16) means -OR(17); R(16) means (C₁-C₆)-alkyl, phenyl or pyridyl; R(17) means hydrogen atom, (C₁-C₅)-alkyl, phenyl or pyridyl, or R(3) means -CHR(18)R(19); R(18) means hydrogen atom or C_zH_2z-R(16) wherein R(16) means abovementioned values; z means 0, 1, 2 or 3; R(19) means -CONH₂; R(4) means hydrogen atom; R(30) and R(31) mean hydrogen atom, and to their pharmaceutically acceptable salts also. Compounds of the formula (I) possess anti-arrhythmic activity and can be used in medicine.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

11 cl, 30 ex