METHOD FOR PREPARING PACLITAXEL Russian patent published in 2006 - IPC C07D305/14 

Abstract RU 2276147 C2

FIELD: organic chemistry, chemical technology, antibiotics, medicine, oncology.

SUBSTANCE: invention relates to a new method for preparing paclitaxel wherein 10-desacetylbaccatin III is used the parent substance and involving simultaneous protection of hydroxyl groups at positions 7 and 10 at the first step. Method is a multistage procedure. Also, invention relates to a new intermediate compound used in this method, representing compound of the formula: wherein R = R1-trichloroacetyl or R'-acetyl and R1 is chosen from tert.-butoxycarbonyl and trichloroacetyl, or they are hydrogen atoms. Invention provides increasing yield of paclitaxel possessing an anti-tumor activity.

EFFECT: improved preparing method.

9 cl, 11 ex

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RU 2 276 147 C2

Authors

Battal'Ja Arturo

Dambruoso Paolo

Guehrrini Andrea

Bombardelli Ehtsio

Pontiroli Alessandro

Dates

2006-05-10Published

2001-12-03Filed