FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to novel C-2'-methylated derivatives of paclitaxel of the formula (I): 
wherein R represents trifluoromethyl group, phenyl, 2-furyl, 2-thienyl; R1 represents tert.-butoxycarbonyl or benzoyl group; R2 represents hydroxy-group; R3 means hydrogen atom or in common with R2 forms residue of cyclic carbonate of the formula: 
under condition that when R3 means hydrogen atom then R is not phenyl. Also, invention relates to a pharmaceutical composition based on thereof and using for preparing medicinal agents possessing an antitumor activity. Invention provides preparing novel derivatives of paclitaxel that possess antitumor activity.
EFFECT: valuable medicinal property of derivatives and pharmaceutical composition.
4 cl, 1 tbl, 6 ex
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