OXCARBAZEPINE-CONTAINING SUSPENSION Russian patent published in 2006 - IPC A61K31/55 A61K9/10 A61K47/38 A61P25/08 

FIELD: pharmaceutical industry.

SUBSTANCE: invention provides pharmaceutical composition useful as anticonvulsive drug to prevent and treat epileptic attacks. Drug is prepared in the form of oxcarbazepine-containing suspension, which, after shake, shows viscosity between 5 and 52 vPa-s. In its preferred embodiment, thixotropic oral suspension contains 5 g/ml oxcarbazepine. In another embodiment, oxcarbazepine suspension includes mixture of carboxymethylcellulose and microcrystalline cellulose in amount between 1.25 and 1.95 g/ml based on total volume of composition. In a still other embodiment, suspension contains oxcarbazepine and less than 0.5 g/ml hydroxyethylcellulose.

EFFECT: avoided lumping during storage period while preserving satisfactory flow characteristics, stability, and good tolerance at oral administration.

13 cl, 3 ex