FIELD: organic chemistry, antibiotics, pharmacy.
SUBSTANCE: invention relates to compound of the formula: wherein R'1 means hydrogen atom; R'2 represents acyl group but with exception of glycyl that is cleaved by mammalian enzyme. Also, invention describes (7R)-7-[(Z)-2-(2-amino-5-chlorothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-{3-[2-N-(L)-aspartylaminoethylthiomethyl]pyrid-4-ylthio}-3-cephem-4-carboxylic acid of the formula: or its pharmaceutically acceptable salt and pharmaceutical composition used in treatment or prophylaxis of bacterial infection and comprising the effective amount of one or more of indicated compounds. The claimed prodrugs show the enhanced solubility in water at neutral or near to neutral pH value as compared with the parent compounds.
EFFECT: improved and valuable properties of prodrugs.
15 cl
Authors
Dates
2006-07-10—Published
2001-03-20—Filed