CEPHALOSPORIN ANTIBIOTICS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF INFECTION Russian patent published in 2006 - IPC C07D501/59 A61K31/546 A61P31/00

Abstract RU 2281948 C2

FIELD: organic chemistry, antibiotics.

SUBSTANCE: invention relates to cephalosporin antibiotics of the chemical formula: or its pharmaceutically acceptable salt wherein R¹ is chosen from the group consisting of the following formula: and R³ is chosen from the group consisting of the following formulae: wherein X represents -NH₂, and n = 0 or 1. Invention proposes a method for treatment of infection caused by methicillin-resistant staphylococci that involves administration in a patient needing this treatment the therapeutically effective dose of cephalosporin antibiotic or its salt. Also, invention proposes an antibacterial composition comprising the therapeutically effective dose of cephalosporin antibiotic or its salt and a pharmaceutically acceptable carrier. Invention provides improved treatment method of infection caused by broad spectrum microorganisms resistant to beta-lactam antibiotics.

EFFECT: improved treatment method, valuable medicinal antibacterial properties of antibiotics.

10 cl, 6 tbl, 2 ex

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RU 2 281 948 C2

Authors

Glinka Tomash U.

Dates

2006-08-20—Published

2001-08-23—Filed