FIELD: medicine, pharmacy.
SUBSTANCE: invention relates to a pharmaceutical composition used in treatment of tuberculosis by preparations based on protionamide. The pharmaceutical composition consists of a core comprising protionamide as an active substance, microcrystalline cellulose, calcium stearate, cellulose derivative, special additives, and envelope comprising cellulose derivative, dye and accessory substance. Hydroxypropylcellulose is used as a derivative of cellulose, and calcium hydrophosphate dihydrate and croscarmelose sodium are used as special additives, and copolymer of vinylpyrrolidone with vinyl acetate taken in the ratio = 6:4 is used as accessory substance in envelope. Invention provides enhancing stability at storage and rapid release of active substance in digestive tract.
EFFECT: improved and valuable pharmaceutical properties of pharmaceutical composition.
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| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITE FORMULATION WITH ANTITUBERCULOUS ACTIVITY | 2003 |
|
RU2247560C1 |
| PHARMACEUTICAL ANTI-TUBERCULOSIS COMBINED COMPOSITION | 2011 |
|
RU2478389C2 |
| COMBINED ANTITUBERCULOUS DRUG AND METHOD FOR PREPARING THEREOF | 2008 |
|
RU2431487C2 |
| ANTI-TUBERCULOSIS MEDICATION BASED ON 4-THIOUREIDOIMINOMETHYLPYRIDINIUM PERCHLORATE, METHOD OF ITS OBTAINING AND METHOD OF TREATMENT | 2010 |
|
RU2423977C1 |
| ANTITUBERCULOUS AGENT | 2003 |
|
RU2247559C1 |
| ANTITUBERCULAR PHARMACEUTICAL COMPOSITION | 2004 |
|
RU2248797C1 |
| COMPOSITE PHARMACEUTICAL COMPOSITION WITH ANTITUBERCULOUS ACTIVITY | 2003 |
|
RU2247561C1 |
| COMBINED ANTI-TUBERCULOSIS PREPARATION | 2007 |
|
RU2354378C1 |
| ANTITUBERCULOUS DRUG AND METHOD OF TREATING | 2010 |
|
RU2449797C1 |
| COFORMULATED ANTITUBERCULOUS DRUG | 2009 |
|
RU2430724C2 |
