COMBINED ANTITUBERCULOUS DRUG AND METHOD FOR PREPARING THEREOF Russian patent published in 2011 - IPC A61K31/7036 A61K31/445 A61K31/495 A61K31/4415 A61K31/4425 A61K9/20 A61P31/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: combined antituberculous drug contains main components in the following proportions (wt %): rifabutin - 4.40-18.5, pyrazinamide - 35.53-56.50, protionamide - 1.52-11.10, pyridoxine hydrochloride - 0.8-1.30. As auxiliary substances, the drug contains colloidal silicon dioxide, gelated starch, potato and/or corn starch, crospovidone, lactose, stearic acid and/or its salts, medium molecular weight polyvinylpyrrolidone, sodium carboxymethyl starch, magnesium hydrosilicate, cellulose microcrystalline, dyes, aromatising agents and/or flavouring additives. The invention also concerns a method for preparing said composition in which each main component passes own stage of wet granulation and drying, then mixed up and tabletted.

EFFECT: combined drug exhibits higher clinical effectiveness in drug-resistant forms of tuberculosis and lower toxicity.

5 cl, 3 tbl