FIELD: medicine, biotechnology.
SUBSTANCE: the present innovation deals with elaborating diagnostic reagents for testing prionic protein in mammalian cerebral tissue due to IEA technique and refers to antibodies specifically reacting with prionic protein PrP or its fragment. The innovation includes polyclonal antibodies obtained to synthetic peptides including amino acid sequences of bovine prionic protein 143-168, 101-134 and 211-241, their conjugates with horseradish peroxidase and diagnostic reagents obtained upon their basis that enable to detect prionic protein in mammalian cerebral tissues.
EFFECT: higher specificity of detection.
15 cl, 8 ex, 8 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| POLYCLONAL ANTIBODY SPECIFICALLY REACTING WITH PRIONIC PROTEIN IN CEREBRAL TISSUE OF MAMMALIANS AND DIAGNOSTIC REAGENT UPON ITS BASIS | 2005 |
|
RU2281511C1 |
| SYNTHETIC PEPTIDE, SYNTHETIC LIPOPEPTIDE, IMMUNOGENIC CONJUGATE (VARIANTS), METHOD OF OLIGOMER PREPARING, POLYSACCHARIDE PROTECTED BY SOLID POLYETHYLENE GLYCOL MONOMETHYL ESTER | 1993 |
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RU2765689C2 |
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| MONOCLONAL ANTIBODY AGAINST THE C-TERMINAL FRAGMENT OF ANTI-MULLERIAN HORMONE | 2021 |
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