DERIVATIVES OF FUMARIC ACID AS NF-kappaB INHIBITOR Russian patent published in 2006 - IPC A61K31/194 A61K31/225 A61P43/00 

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention proposes using one or some unsubstituted or substituted fumaric acid monoalkyl and dialkyl esters as a specific inhibitor of transcription NF-kappa B-dependent gene as a component of pharmaceutical composition used in treatment of NF-kappa B-mediated diseases. Diseases are chosen from the group consisting of diffuse systemic scleroderma, syphilitic osteochondrotis (Veger's disease), Cutis marmorata, (Livedo Reticularis), Behcet's disease, panartheriitis, nonspecific ulcerous colitis, vasculitis, osteoarthritis, gout, arteriosclerosis, Reiter's syndrome, broncho-pulmonary granulomatosis, encephalitis types, endotoxic shock (septic-toxic shock), sepsis, pneumonia, encephalomyelitis, nervous-psychic anorexia, Rennert's T-lymphomatosis, mesangial nephritis, post-angioplasty restenosis, cytomegalovirus retinopathy, adenoviral diseases, such as adenoviral cold diseases, adenoviral pharyngo-conjunctival fever and adenoviral ophthalmia, AIDS, Guillain-Barr syndrome, post-herpetic neuralgia or neuralgia after shingles, inflammatory demyelinizing polyneuropathy, multiple mononeuropathy, mucoviscidosis, Bekhterev's disease, Berret's esophagus ulcer, infection with Epstein-Barr virus (EBV), cardiac re-modeling, interstitial cystitis, diabetes mellitus type II, radio-sensitized malignant tumors, partial resistance of malignant cells to chemotherapeutic agents (resistance to many medicinal agents used in chemotherapy), ring-shaped granulomas and oncological diseases, such as breast cancer, colon cancer, melanoma, primary carcinoma of liver cells, adenocarcinoma, Kaposi's sarcoma, prostate cancer, leukosis, such as acute myeloid leukosis, multiple myeloma (plasmocytoma), Burkitt's lymphoma and Kastleman's tumor. The selective inhibition of indicated receptors provides carrying out the suppression of inflammation in treatment of above enumerated diseases.

EFFECT: valuable medicinal properties of substances.

10 cl, 2 tbl, 7 ex