FIELD: biotechnology.
SUBSTANCE: method for production L-histidine includes culturing of Escherichia genus bacteria, containing DNA fragment encoding of mutant bacterial phosphoribozyl pyrophosphate synthetase (FRPP-synthetase), and collection of produced and accumulated L-histidine from cultural liquid, wherein in mutant FRPP-synthetase L-amino acid residue, corresponding to 115-position of amino acid sequence in natural FRPP-synthetase from Escherichia coli is replaced by serine residue.
EFFECT: high effective method for production of L-histidine.
11 cl, 1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| BACTERIUM BELONGING TO GENUS Escherichia AS PRODUCER OF L-HISTIDINE AND METHOD FOR PREPARING L-HISTIDINE | 2003 |
|
RU2276688C2 |
| BACTERIUM BELONGING TO GENUS ESCHERICHIA AS PRODUCER OF L-HISTIDINE AND METHOD FOR PREPARING L-HISTIDINE | 2003 |
|
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| METHOD OF OBTAINING L-AMINO ACIDS USING BACTERIA OF FAMILY ENTEROBACTERIACEAE | 2007 |
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| METHOD OF PRODUCING L-threonine WITH USING BACTERIUM OF Escherichia TYPE | 2006 |
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RU2351646C2 |
| SMALL SUBUNIT OF ISOZYME III AND ISOZYME III OF ACETOHYDROXYACID SYNTHETASE FROM ESCHERICHIA COLI, DNA FRAGMENT (VARIANTS), STRAIN OF BACTERIUM ESCHERICHIA COLI AS PRODUCER OF L-VALINE (VARIANTS) AND METHOD FOR PREPARING L-VALINE | 2000 |
|
RU2209246C2 |
| METHOD FOR PREPARING L-AMINO ACIDS USING MICROORGANISM BELONGING TO GENUS ESCHERICHIA | 2005 |
|
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| METHOD FOR OBTAINING L-AMINO ACID USING BACTERIUM OF Enterobacteriaceae FAMILY, WHICH HAS INCREASED EXPRESSION OF GENES OF STAGE OF FORMATION OF FLAGELLA AND CELLULAR MOVABILITY | 2012 |
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RU2508404C1 |
| METHOD OF OBTAINING L-AMINO ACID | 2008 |
|
RU2515044C2 |
| METHOD FOR OBTAINING L-AMINOACID USING BACTERIUM OF Enterobacteriaceae FAMILY | 2010 |
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RU2501857C2 |
| METHOD FOR PRODUCING L-AMINO ACIDS WITH USE OF BACTERIA OF ENTEROBACTERIACEAE FAMILY | 2010 |
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RU2460793C2 |
