METHOD FOR PREPARING THIAZOLE DERIVATIVES POSSESSING PESTICIDE ACTIVITY Russian patent published in 2006 - IPC C07D417/06 C07D277/32 

FIELD: organic chemistry, chemical technology, pesticides.

SUBSTANCE: invention relates to a method for synthesis of compound of the formula (I): wherein Q means nitrogen atom (N); Y means nitro-group (-NO₂); Z means -NR₃; R₁ and R₂ mean in common alkylene bridge that comprises two or three carbon atoms and, optionally, a heteroatom chosen from the group comprising -NR₅ and oxygen atom (O); R₃ means unsubstituted (C₁-C₁₂)-alkyl; R₅ means hydrogen atom (H) or (C₁-C₁₂)-alkyl. Method involves the following steps: (a) interaction of compound of the formula (II): wherein X means a leaving group with a halogenated agent to yield compound of the formula (III): wherein W means halogen atom and wherein treatment of compound of the formula (III) involves extraction of compound of the formula (III) with hydrochloric acid taken in the concentration 10-50 wt.-%, and (b) interaction of the synthesized compound of the formula (III) with compound of the formula (IV): wherein R₁, R₂, Y, Z and Q have above given values. In the process for synthesis of compound of the formula (III) the stage (a) involves purification stage wherein formed crude product is treated with water at acid range of pH values.

EFFECT: improved method of synthesis.

3 cl, 6 ex