FIELD: pharmaceutics.
SUBSTANCE: invention concerns novel compounds of the formula I 
, where R3 is (4-methylpiperazinyl)methyl and the other four radicals R1, R2, R4, and R5 are independently hydrogen; cyano; lower alkyl; hydroxy- or amino-substituted simple alkyl; trifluoromethyl; free or etherified hydroxy-group; (lower)alkoxy; (lower)alkanoyloxy; free, alkylated or acylated amino group; mono- or di(lower)alkylamino; (lower)alkanoylamino; benzoylamino; free or etherified carboxy-group; (lower)alkoxycarbonyl, and halogen; R6 is halogen, NH2, NO2, NHC(O)CF3, NHC(O)CH3 or NHC(NH)NH2, R7 is methyl, and R8 is hydrogen; or the compound salt, or crystalline form, method of obtainment, application in obtaining compound of the formula IV, and pharmaceutical composition for leukemia treatment, based on the claimed compounds.
EFFECT: novel compounds applicable in obtaining compounds inhibiting tyrosine kynase of epidermal growth factor (EGF) receptor.
13 cl, 12 ex
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