METHOD OF SYNTHESIS OF THIAZOLE DERIVATIVES, INTERMEDIATE COMPOUND AND METHOD OF ITS SYNTHESIS Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to novel method of synthesis of compound of the formula (I) in each case in free form and as salt where Q means CH or N; Y means NO₂ or CN; Z means CHR₃, O, NR₃ or S; R₁ and R₂ each means independently hydrogen atom, unsubstituted or R₄-substituted C₁-C₈-alkyl or in common they form alkylene bridge consisting of two or three carbon atoms being alkylene bridge can comprise additionally heteroatom taken among group including NR₅, O or S; R₃ means H, unsubstituted or R₄-substituted C₁-C₁₂-alkyl; R₄ means unsubstituted or substituted aryl or heteroaryl; R₅ means H or C₁-C₁₂-alkyl. Method involves conversion of compound of the formula (II) where R means cyclohexyl, phenyl, benzyl or group of the formula (a) ; X₁ means group to be eliminated with halogenating agent to compound of the formula (IV) where X means halogen atom and conversion of synthesized compound of the formula (IV) to compound of the formula (VI) by interaction with compound of the formula (V) that is converted to compound of the formula (I) using chlorinating agent being in compound of the formula (IV) values R, X, X₁ are indicated above. Invention relates also to method of synthesis of compound of the formula (IV) involving interaction of compound of the formula (II) with halogenating agent. EFFECT: improved method of synthesis of thiazole derivatives. 6 cl, 6 tbl, 16 ex