FIELD: pharmaceuticals, organic chemistry.
SUBSTANCE: invention relates to ecteinascidin derivatives of general formula I 
, wherein R1 represents H, OR', halogen; R2 and R3 are independently selected from H, R', C(=)R', C(=O)OR'; R4 represents H, C1-C25-alkyl, C2-C18-alkenyl, and C(=O)OR'; R5 represents H, OR', halogen, and C1-C25-alkyl; R' is independently selected from OH or CN; m and n = 0 or 1. Claimed compounds are useful as antitumor agents. Pharmaceutical composition also is disclosed.
EFFECT: new antitumor agents.
24 cl, 68 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ECTEINASCEDIN DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USES THEREOF | 2003 |
|
RU2306316C9 |
| DERIVATIVES OF VARIOLIN B, METHOD FOR THEIR PREPARING, INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION | 2001 |
|
RU2293737C2 |
| SEMISYNTHETIC METHOD AND NEW COMPOUNDS | 2000 |
|
RU2237063C9 |
| ANTICANCER DIHYDROPYRAN-3-ONE COMPOUNDS | 2007 |
|
RU2444519C2 |
| TRI- OR TETPA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES | 2006 |
|
RU2420524C2 |
| GENERAL SYNTHESIS OF MYRIAPORONES | 2003 |
|
RU2328492C2 |
| PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | 2015 |
|
RU2687160C2 |
| PICOLINAMIDES WITH FUNGICIDAL ACTIVITY | 2015 |
|
RU2703402C2 |
| PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | 2015 |
|
RU2708392C2 |
| PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | 2015 |
|
RU2797810C2 |
