2-((4-(4-(BENZYLOXY)PYRIMIDIN-2-YL)PIPERAZIN-1-YL)METHYL)-1H-BENZO[d]IMIDAZOLE DERIVATIVES AS LOW-MOLECULAR GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS Russian patent published in 2025 - IPC C07D413/14 A61K31/4545 A61K31/506 A61P3/10 

Abstract RU 2838323 C1

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula ,

where R1 represents a carboxyl group or 3-methyl-1,2,4-oxadiazol-5-yl as a substitute: , R2 is an alkyl (C1-C5), cyclopropylmethyl, propargyl, 2,2,2-trifluoroethyl or ether substitute from the row:

, R3 represents: H, CH3.

EFFECT: novel low-molecular glucagon-like peptide-1 (GLP-1) receptor agonists are synthesized; the invention enables to expand the range of low-molecular GLP-1 receptor agonists.

19 cl, 9 dwg, 3 tbl, 82 ex

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RU 2 838 323 C1

Authors

Tolkacheva Elena Vladimirovna

Salakhov Tagir Lenarovich

Saliev Aleksandr Yurevich

Krasnodubets Alisa Mikhajlovna

Ivanov Roman Alekseevich

Chernyshov Vladimir Vladimirovich

Dates

2025-04-14Published

2024-12-13Filed