ANTICANCER DIHYDROPYRAN-3-ONE COMPOUNDS Russian patent published in 2012 - IPC C07D309/32 A61K31/351 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new dihydropyran-2-one of formula

, where R₁ is selected from hydrogen, OR_a, OCOR_a, OCOOR_a, NR_aR_b, NR_aCOR_b and NR_aC(NR_a)NR_aR_b; each R₂ and R₃ are optionally selected from hydrogen, substituted or unsubstituted C₁-C₁₂ alkyl, substituted or unsubstituted C₂-C₁₂ alkenyl and substituted or unsubstituted C₂-C₁₂ alkynyl; each R₄₁, R₄₂, R₄₃, R₄₄, R₄₅, R₄₆, R₄₇ and R₄₈ are optionally selected from hydrogen, substituted or unsubstituted C₁-C₁₂ alkyl, substituted or unsubstituted C₂-C₁₂ alkenyl and substituted or unsubstituted C₂-C₁₂ alkynyl; each R₅, R₆ and R₇ are optionally selected from hydrogen, COR_a, COOR_a, substituted or unsubstituted C₁-C₁₂ alkyl, substituted or unsubstituted C₂-C₁₂ alkenyl and substituted or unsubstituted C₂-C₁₂ alkynyl, or R₅ and R₄₈ together with coupled atom N and atom C whereto attached can form substituted or unsubstituted heterocyclic group; each R_a and R_b are optionally selected from hydrogen, substituted or unsubstituted C₁-C₁₂ alkyl, substituted or unsubstituted C₂-C₁₂ alkenyl, substituted or unsubstituted C₂-C₁₂ alkynyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclic group; and each dashed line means an optional additional bond; to its pharmaceutically acceptable salts, tautomers or stereoisomers.

EFFECT: development of the method for preparing an anticancer composition, and the method of treating cancer.

46 cl, 10 tbl, 12 ex