FIELD: medicine, hepatology, immunology.
SUBSTANCE: invention proposes using an opioid peptide DSLET of the formula: Tyr-D-Ser-Gly-Phe-Leu-Thr used for stimulation of reparative regeneration of liver and correction of immune reactivity under conditions of toxic hepatopathy. Opioid peptide DSLET is administrated by parenteral route (intaperitoneally) in the dose 50 mcg/kg of body mass in 0.1 ml of physiologically solution in course for 10 doses with break for 24 h between injections to experimental animal (rat) with toxic hepatopathy. The advantage of invention involves the possibility for using this peptide in toxic hepatopathy. Invention can be used for stimulation of regeneration of hepatocytes and correction of immune reactivity in experimental toxic hepatopathy.
EFFECT: valuable medicinal properties of agent.
2 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR STIMULATION OF PHYSIOLOGICAL AND REPARATIVE REGENERATION OF LIVER | 2002 |
|
RU2214269C1 |
| METHOD OF CORRECTION OF BIOCHEMICAL AND IMMUNOLOGICAL DISTURBANCES AT CONDITION OF EXPERIMENTAL ACUTE TOXIC HEPATOPATHY ACCOMPANYING WITH ENHANCEMENT OF IMMUNOLOGICAL REACTIVITY | 2002 |
|
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| METHOD FOR STIMULATION OF REPARATIVE LIVER REGENERATION AFTER ITS RESECTION | 2016 |
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| USE OF H2N-D-Ala-L-Glu-L-Trp-COOH PEPTIDE FOR HEPATOPROTECTIVE EFFECTS. | 2021 |
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| HEPATOPROTECTIVE AGENT WITH ANTIOXIDANT AND REPARATIVE ACTIVITIES | 2021 |
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RU2782881C1 |
| METHOD FOR STIMULATING HEPATIC TISSUE REPAIR | 1999 |
|
RU2185835C2 |
| ORAL PHARMACEUTICAL COMPOSITION FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES | 2010 |
|
RU2445965C2 |
| APPLICATION OF OPIOID PEPTIDE DAGO FOR STIMULATION OF REPARATIVE OSTEOGENESIS IN LABORATORY ANIMALS | 2000 |
|
RU2195311C2 |
| METHOD OF STIMULATION OF HEPATIC TISSUE REGENERATION | 1997 |
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RU2134582C1 |
| PEPTIDES SHOWING REGENERATIVE-REPARATIVE ACTION | 1994 |
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RU2065445C1 |
