METHOD OF CORRECTION OF BIOCHEMICAL AND IMMUNOLOGICAL DISTURBANCES AT CONDITION OF EXPERIMENTAL ACUTE TOXIC HEPATOPATHY ACCOMPANYING WITH ENHANCEMENT OF IMMUNOLOGICAL REACTIVITY Russian patent published in 2003 - IPC

Abstract RU 2205658 C1

FIELD: medicine, hepatology, immunology, biochemistry. SUBSTANCE: invention relates to development of method for correction of biochemical and immunological shifts at conditions of acute toxic hepatopathy accompanying with enhancement of immunological reactivity. For this purpose experimental animal is administrated by parenteral (intraperitoneal) route tripeptide H2N-Gly-L-His-L-Lys-COOH dissolved in sodium chloride solution in the dose 1.5 mcg/kg of body mass, 10 times with interval for 24 h between injections. Method provides arresting hyperactivation of immune system that inhibits the development of autoimmune process. EFFECT: enhanced effectiveness of method. 2 tbl, 1 dwg, 1 ex

Similar patents RU2205658C1

Title Year Author Number
AGENT FOR STIMULATION OF REPARATIVE REGENERATION OF LIVER AND CORRECTION OF IMMUNE REACTIVITY IN EXPERIMENTAL TOXIC HEPATOPATHY 2005
  • Smakhtin Mikhail Jur'Evich
  • Sever'Janova Ljudmila Anatol'Evna
  • Bobyntsev Igor' Ivanovich
  • Konoplja Aleksej Aleksandrovich
RU2286794C1
METHOD FOR STIMULATION OF PHYSIOLOGICAL AND REPARATIVE REGENERATION OF LIVER 2002
  • Smakhtin M.Ju.
  • Shvejnov I.A.
  • Konoplja A.A.
  • Sever'Janova L.A.
  • Bobyntsev I.I.
RU2214269C1
METHOD FOR STIMULATING REGENERATION OF INFECTED WOUNDS ON SKIN AND SOFT TISSUES USING Gly-His-Lys-D-Ala PEPTIDE 2018
  • Rakhmetova Kamila Kamildzhanovna
  • Bobyntsev Igor Ivanovich
  • Bezhin Aleksandr Ivanovich
  • Smakhtin Mikhail Yurevich
  • Gribanova Elena Aleksandrovna
RU2681216C1
USE OF PEPTIDE Gly-His-Lys FOR ANXIOLYTIC EFFECT 2012
  • Dolgintsev Maksim Evgen'Evich
  • Bobyntsev Igor' Ivanovich
  • Smakhtin Mikhail Jur'Evich
  • Chernysheva Ol'Ga Igorevna
  • Belykh Andrej Evgen'Evich
  • Krjukov Aleksej Anatol'Evich
RU2480232C1
SKIN AND SOFT TISSUES INFECTED WOUNDS PRIMARY SURGICAL TREATMENT METHOD USING THE Gly-His-Lys-D-Ala PEPTIDE 2018
  • Rakhmetova Kamila Kamildzhanovna
  • Bobyntsev Igor Ivanovich
  • Bezhin Aleksandr Ivanovich
  • Smakhtin Mikhail Yurevich
  • Mishina Ekaterina Sergeevna
  • Khoryakov Maksim Yurevich
RU2681310C1
APPLICATION OF PEPTIDE Gly-His-Lys FOR ANALGESIC EFFECT IN PAIN CAUSED BY THERMAL IRRITATION 2010
  • Dolgintsev Maksim Evgen'Evich
  • Bobyntsev Igor' Ivanovich
  • Smakhtin Mikhail Jur'Evich
  • Krjukov Aleksej Anatol'Evich
  • Ivanova Ol'Ga Igorevna
  • Belykh Andrej Evgen'Evich
RU2421235C1
HEPATOPROTECTIVE AGENT WITH ANTIOXIDANT AND REPARATIVE ACTIVITIES 2021
  • Chulanova Anna Aleksandrovna
  • Smakhtin Mikhail Iurevich
  • Bobyntsev Igor Ivanovich
  • Mishina Ekaterina Sergeevna
  • Artiushkova Elena Borisovna
  • Furman Iurii Vasilevich
  • Smakhtina Angelina Mikhailovna
RU2782881C1
USE OF H2N-D-Ala-L-Glu-L-Trp-COOH PEPTIDE FOR HEPATOPROTECTIVE EFFECTS. 2021
  • Chulanova Anna Aleksandrovna
  • Smakhtin Mikhail Iurevich
  • Bobyntsev Igor Ivanovich
  • Mishina Ekaterina Sergeevna
  • Artiushkova Elena Borisovna
  • Furman Iurii Vasilevich
  • Smakhtina Angelina Mikhailovna
RU2790871C1
METHOD FOR STIMULATION OF REPARATIVE LIVER REGENERATION AFTER ITS RESECTION 2016
  • Solin Aleksej Vladimirovich
  • Lyashev Yurij Dmitrievich
  • Lyashev Andrej Yurevich
RU2636194C1
APPLICATION OF Thr-Lys-Pro-Arg-Pro-Gly-Pro PEPTIDE (SELANK) FOR TOXIC HEPATITIS PREVENTION AND TREATMENT 2017
  • Andreeva Lyudmila Aleksandrovna
  • Nemerskij Evgenij Alimovich
  • Petrovskij Aleksej Konstantinovich
  • Petrovskaya Anastasiya Yurevna
  • Smirnov Nikolaj Alekseevich
  • Fedorov Vladimir Nikolaevich
  • Fedorova Tatyana Borisovna
RU2640133C1

RU 2 205 658 C1

Authors

Smakhtin M.Ju.

Konoplja A.I.

Sever'Janova L.A.

Bobyntsev I.I.

Dates

2003-06-10Published

2002-02-11Filed