DERIVATIVES OF IMIDAZOLIDINE AS INHIBITORS OF PEPTIDE DEFORMYLASE Russian patent published in 2006 - IPC C07D233/78 C07D413/06 C07D405/06 A61K31/4166 A61K31/4178 A61P31/04 

FIELD: organic chemistry, biochemistry, medicine.

SUBSTANCE: invention relates to novel derivatives of imidazolidine and describes compound of the formula (I): wherein R1 is chosen from the group consisting of (C₁-C₉)-alkyl, (C₁-C₂)-alkyl-Ar; R2 is chosen from the group consisting of phenyl, (C₁-C₄)-alkyl-Ar', -NC(O)R4, (C₂-C₄)-alkyl-NR3R4, (C₁-C₃)-alkyl-C(O)-Ar'; R3 is chosen from the group consisting of hydrogen atom (H), (C₁-C₂)-alkyl-Ar and Ar; R4 represents R3, or R4 can be taken in common with R3 and nitrogen atom to which they are bound for formation of morpholinyl; Ar is chosen from the group consisting of phenyl that can be optionally substituted with one, two or three substitutes chosen from the group consisting of F, Cl, Br and J; Ar' is chosen from the group consisting of phenyl, biphenyl, benzofuranyl and benz[b]thiophene that can be optionally substituted with one, two or three substitutes chosen from the group consisting of (C₁-C₆)-alkyl, -(CH₂)_0-5CO₂R1, F, Cl, Br, J and COOH; A is chosen from -C(O)NHOH or -N(CHO)OH; X means -NH if Y means -C(O), or its pharmaceutically acceptable salt. Also, invention describes a method for treatment of bacterial infection based on compounds of the formula (I). Invention provides preparing novel compounds possessing the useful biological properties.

EFFECT: valuable medicinal and biochemical properties of compounds.

4 cl, 3 ex