FIELD: organic chemistry, biochemistry, medicine, pharmacy.
SUBSTANCE: invention describes compound of the formula (I): wherein X represents -NR1; Y1 and Y2 represent oxygen atom (O); Z is chosen from -SO2N(R6), -N(R7)SO2; m = 1 or 2; A is chosen from a direct bond, (C1-C6)-alkyl; R1 represents hydrogen atom (H); each R2 and R3 is chosen independently from H, alkyl, aryl, alkylaryl, arylalkyl; each R4 is chosen independently from H, (C1-C3)-alkyl; R6 is chosen from H, alkyl, aryl, heteroaryl, alkylaryl, alkyl-heteroaryl, arylalkyl, heteroaryl-alkyl; R2 and R6 can join to form a ring comprising up to 7 ring atoms, or R3 and R6 can join to form a ring comprising up to 7 ring atoms, or R4 and R6 can join to form a ring comprising up to 7 ring atoms; R5 represents monocyclic, bicyclic or tricyclic group comprising one or two ring structures wherein each of that comprises up to 7 ring atoms chosen independently from cycloalkyl, aryl, heterocycloalkyl or heteroaryl and possibly substituted; when R5 represents bicyclic group then each ring structure is bound with the next ring structure through a direct bond, through -O-, through (C1-C6)-alkyl or condensed with this next ring structure; R7 is chosen from (C1-C6)-alkyl. Also, invention describes compound of the formula (II) given in the description, pharmaceutical compositions and using compound of the formula (I) or the formula (II) in preparing a medicine for using in treatment of disease or state mediated by one or more enzymes and representing metalloproteinase. Represented compounds are useful as inhibitors of metalloproteinases and especially as inhibitors of MMP12.
EFFECT: valuable medicinal and biochemical properties of inhibitors and pharmaceutical compositions.
20 cl, 3 tbl, 6 ex
Title | Year | Author | Number |
---|---|---|---|
INHIBITORS OF METALLOPROTEINASES, THEIR USING AND PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF | 2002 |
|
RU2293730C2 |
INHIBITORS OF METALLOPROTEINASES, THEIR USING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2002 |
|
RU2288228C2 |
DERIVATIVES OF IMIDAZOLIDINE-2,4-DIONE, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AND THEIR USING | 2002 |
|
RU2285695C2 |
NEW HYDANTOIC DERIVATIVES FOR TREATING OBSTRUCTIVE AIRWAY DISEASES | 2005 |
|
RU2386629C2 |
2,5-DIOXOIMIDAZOLIN-4-YL METHYLCARBONYL COMPOUNDS, METHOD OF OBTAINING THEM, PHARMACEUTICAL MIXTURES CONTAING THEM AND THIR USE IN MEDICINE PREPARATION | 2003 |
|
RU2326117C2 |
NEW DERIVATIVES OF HYDANTOIN AS INHIBITORS OF METAL PROTEINASES | 2005 |
|
RU2376301C2 |
P38 KINASE-INHIBITING ISOQUINOLINE DERIVATIVES | 2009 |
|
RU2512318C2 |
NOVEL HYDANTOIN DERIVATIVES AS METALLOPROTEINASE INHIBITORS | 2005 |
|
RU2378269C2 |
HYDANTOIN DERIVATIVES USED AS MMP INHIBITORS | 2007 |
|
RU2463301C2 |
METHOD FOR PREPARING PYRAZOLE-CARBOXYLIC ACID DERIVATIVES | 2013 |
|
RU2638112C2 |
Authors
Dates
2007-02-20—Published
2002-03-13—Filed