FIELD: chemistry of heterocyclic organic compounds, medicine.
SUBSTANCE: invention relates to a novel heterocyclic derivative of the formula (I'): 
, wherein R1 represents hydrogen atom or (C1-C6)-alkyl; R2 represents-CO-C(R4)=C(R4)-R5 wherein R4 represents hydrogen atom; R5 represents (C2-C8)-alkenyl; R3 represents hydrogen atom or (C1-C4)-alkyl; X represents oxygen atom or sulfur atom; R20 represents phenyl substituted with unsubstituted (C1-C6)-alkyl, (C1-C6)-alkyl substituted with fluorine atom, (C1-C4)-alkoxy-group, phenyl-(C1-C4)-alkoxy-group, hydroxyl group, halogen atom, nitro-group, unsubstituted amino-group or amino-group substituted with (C1-C4)-alkyl; n means a whole number from 1 to 4, or to its pharmaceutically acceptable salt. Also, invention relates to heterocyclic derivative of the formula (I): 
, wherein R1 represents hydrogen atom or (C1-C6)-alkyl; R2 represents -CO-C(R4)=C(R4)-R5 wherein R4 represents hydrogen atom; R represents (C4-C8)-alkyl or (C2-C8)-alkenyl or -CO-C≡C-R6 wherein R6 represents (C1-C8)-alkyl; R3 represents hydrogen atom or (C1-C4)-alkyl; X represents oxygen atom or sulfur atom; n means a whole number from 1 to 4, or its pharmaceutically acceptable salt. Compounds of the formulas (I') and (I) are effective as a hypoglycemic agent, hypolipidemic agent, agent improving resistance to insulin, therapeutic agent in treatment of diabetes mellitus, therapeutic agent in treatment of diabetes mellitus complications, agents enhancing tolerance to glucose, anti-arteriosclerotic agent, agents against obesity or agent for X syndrome.
EFFECT: valuable medicinal properties of derivatives.
14 cl, 2 tbl, 56 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF TETRAHYDROISOQUINOLINE AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2000 |
|
RU2256661C2 |
| HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL AGENT BASED ON THEREOF AND METHOD OF TREATMENT | 2002 |
|
RU2299197C2 |
| NOVEL PHOSPHATE COMPOUNDS, SYNTHESIS METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | 2014 |
|
RU2617682C2 |
| OXAZOLE DERIVATIVES SUBSTITUTED WITH CARBOXYLIC ACIDS AS PPAR-ALPHA AND PPAR-GAMMA ACTIVATORS IN DIABETES TREATMENT | 2002 |
|
RU2278859C2 |
| DIHYDRONAPHTHALENE DERIVATIVES AND MEDICINAL AGENT COMPRISING INDICATED DERIVATIVES AS ACTIVE COMPONENT | 2001 |
|
RU2268262C2 |
| NOVEL INDOLYSIN COMPOUNDS, METHOD FOR PRODUCING AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF | 2014 |
|
RU2693629C2 |
| PIPERIDINE DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND PHARMACEUTICAL USE THEREOF | 2016 |
|
RU2730508C2 |
| NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION BASED THEREON, USE THEREOF AND METHOD OF TREATING AND/OR PREVENTING DISEASE | 2009 |
|
RU2474575C2 |
| AMINOPYRAZOLOPYRIMIDINE COMPOUND USED AS INHIBITOR OF TYROSINE KINASE RECEPTOR OF NEUROTROPHIC FACTOR | 2017 |
|
RU2764523C2 |
| METHOD OF SYNTHESIS OF PYRAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1990 |
|
RU2021990C1 |
