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(19)

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2 299 197

(13)

(51)

IPC

C07D217/26(2006-01-01)

C07D413/12(2006-01-01)

C07D417/12(2006-01-01)

A61K31/472(2006-01-01)

A61K31/4725(2006-01-01)

A61P3/06(2006-01-01)

A61P3/10(2006-01-01)

C07D263/32(2006-01-01)

C07D277/22(2006-01-01)

(21) (22)

Application

2003137574/04, 2002-05-27

(24)

Start date

2002-05-27

(22)

Actual filing date

2002-05-27

(45)

Published

2007-05-20

(72)

Inventor

Matsui KhirosiKobajasi KhideoAzukizava SatoruKasai MasajasuJosimi AkikhisaSirakhase Khiroaki

(73)

Holder

Kioto Farmas'Jutikal Indastriz, Ltd.

HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL AGENT BASED ON THEREOF AND METHOD OF TREATMENT Russian patent published in 2007 - IPC C07D217/26 C07D413/12 C07D417/12 A61K31/472 A61K31/4725 A61P3/06 A61P3/10 C07D263/32 C07D277/22

Abstract RU 2299197 C2

FIELD: chemistry of heterocyclic compounds, medicine, pharmacy.

SUBSTANCE: invention relates to novel heterocyclic compounds of the general formula (I): wherein R¹ represents hydrogen atom or (C₁-C₆)-alkyl; R² represents hydrogen atom, -CO-R³ wherein R³ represents (C₂-C₆)-alkyl substituted optionally with halogen atom, -CO-C(R⁴)=C(R⁴)-R⁵ wherein R⁴ represents hydrogen atom or (C₁-C₄)-alkyl; R⁵ represents (C₁-C₈)-alkyl, (C₂-C₈)-alkenyl and others; Y represents compound of the formula: wherein R⁷ represents hydrogen atom or (C₁-C₄)-alkyl; R⁸ represents (C₅-C₈)-alkyl, (C₄-C₈)-cycloalkyl and others; X represents oxygen atom or sulfur atom and others. Also, invention relates to pharmaceutically acceptable salts of these compounds. Compounds of the formula (I) possess hypoglycemic and/or hypolipidemic activity and can be used in medicine in treatment of diabetes mellitus, hyperlipidemia, hyperglycemia, diseases caused by resistance to insulin and other diseases.

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.

28 cl, 3 tbl, 131 ex

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RU 2 299 197 C2

Authors

Matsui Khirosi

Kobajasi Khideo

Azukizava Satoru

Kasai Masajasu

Josimi Akikhisa

Sirakhase Khiroaki

Dates

2007-05-20—Published

2002-05-27—Filed