FIELD: biotechnology, medicine, oncology.
SUBSTANCE: invention relates to a novel human melanoma cellular line mel Ibr possessing stable cultural and morphological indices that is stored in the Specialized collection of cellular cultures in Cytology institute RAS at number PKKK (P) 689D. The cellular line is characterized by expression of melanoma (differentiating) markers - CD-63, HMW and cancer-testicular marker MAGE-3, the presence of histo-compatibility antigens of the first and the second class. The cellular line can be used in creature of antitumor (all-cellular, genetic engineering) vaccines used in treatment of melanoma and other malignant neoplasms. Using this cellular line provides preparing the novel effective antitumor vaccine. Invention can be used in medicine for vaccine therapy of malignant neoplasms.
EFFECT: valuable medicinal properties of cellular line.
1 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMAN MELANOMA CELLULAR LINE mel Kor USED IN PREPARING ANTITUMOR VACCINE | 2005 |
|
RU2287578C1 |
| HUMAN MELANOMA CELLULAR LINE mel P USED IN PREPARING ANTITUMOR VACCINE | 2005 |
|
RU2287575C1 |
| HUMAN MELANOMA CELLULAR LINE mel IL USED IN PREPARING ANTITUMOR VACCINE | 2005 |
|
RU2287577C1 |
| HUMAN MELANOMA CELL LINE mel Ch, USED FOR MAKING ANTI-TUMOUR VACCINES | 2008 |
|
RU2373279C1 |
| HUMAN MELANOMA CELL LINE mel Gus, USED FOR MAKING ANTI-TUMOUR VACCINES | 2008 |
|
RU2373280C1 |
| CELL LINE OF HUMAN MELANOMA mel H, APPLIED FOR OBTAINING ANTITUMOUR VACCINE | 2009 |
|
RU2402604C1 |
| HUMAN MELANOMA CELL LINES mel Si, USED FOR MAKING TUMOUR VACCINE | 2008 |
|
RU2363734C1 |
| CELL LINE OF HUMAN MELANOMA mel Cher, USED FOR OBTAINING ANTI-TUMOR VACCINES | 2008 |
|
RU2364624C1 |
| CELL LINE OF HUMAN MELANOMA mel Rac, APPLIED FOR OBTAINING ANTITUMOUR VACCINE | 2009 |
|
RU2402602C1 |
| CELL LINE OF HUMAN MELANOMA mel Mtp USED FOR MAKING ANTICANCER VACCINES | 2008 |
|
RU2360963C1 |
