ANALOGS OF FATTY ACIDS, METHOD FOR THEIR PREPARING, METHOD FOR TREATMENT OF DISEASES, PHARMACEUTICAL COMPOSITION AND NUTRIENT COMPOSITION COMPRISING ANALOGS THEREOF AND METHOD FOR PROVIDING BODY MASS LOSS Russian patent published in 2006 - IPC C07C57/03 C07C57/18 C07C321/18 A61K31/20 A61K31/201 A61P3/04 A61P3/10 A61P9/10 A61P9/12 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel analogs of fatty acids of the general formula (I): R₁-[X_i-CH₂]_n-COOR₂ wherein R₁ represents (C₆-C₂₄)-alkene with one or more double bond, and/or (C₆-C₂₄)-alkyne; R₂ represents hydrogen atom or (C₁-C₄)-alkyl; n represents a whole number from 1 to 12; I represents an uneven number and shows position relatively to COOR₂; X_i is chosen independently of one another from the group comprising oxygen (O), sulfur (S) and selenium (se) atom and -CH₂ under condition that at least one among X_i is not -CH₂ and under condition that if R₁ represents alkyne then a carbon-carbon triple bond is located between (ω-1)-carbon atom and (ω-2)-carbon atom, or between (ω-2)-carbon atom and (ω-3)-carbon atom, or between (ω-3)-carbon atom and (ω-4)-carbon atom, and to their salts and complexes. The claimed compounds can be used in treatment and/or prophylaxis of X syndrome, obesity, hypertension, hepatic fatty dystrophy, diabetes mellitus, hyperglycemia, hyperinsulinemia and stenosis. Also, invention relates to methods for preparing novel analogs of fatty acids. Also, invention relates to a nutrient composition comprising indicated analogs of fatty acids and to a method for reducing the total body mass or amount of lipid tissue in humans or animals. Invention provides the development of novel fatty acid analogs-base compositions or methods for suppression of stenosis, restenosis or associated disorders as result of proliferation and mobilization of vessel smooth muscle cells after, for example, traumatic damages of vessels during surgery operation in vessels.

EFFECT: improved preparing method, valuable medicinal properties of analogs.

12 cl, 2 dwg, 7 ex