NOVEL SUBSTITUTED INDOLES Russian patent published in 2006 - IPC C07D209/30 C07D403/12 C07D413/12 C07D417/12 A61K31/405 A61K31/4178 A61K31/4196 A61P11/06 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel substituted indoles or its pharmaceutically acceptable salts of the formula (I): , wherein R¹ means hydrogen (H) atom, halogen atom, -CN, nitro-group, -SO₂R⁴, -OH, -OR⁴, -SO₂NR⁵R⁶, -CONR⁵R⁶, -COOH, -COOCH₃, -NR⁵R⁶, phenyl, naphthyl or (C₁-C₆)-alkyl wherein the latter group is possibly substituted with one or more substitutes chosen independently from halogen atom, -OR⁸ and -NR⁵R⁶ wherein x = 2; R² means (C₁-C₇)-alkyl; R³ means phenyl, naphthyl or heteroaryl and each of them is possibly substituted with one or more substitutes chosen independently from H, halogen atom, -CN, -OH, -SO₂R⁴, -OR⁴, -SO₂NR⁵R⁶, -CONR⁵R⁶, phenyl, naphthyl, (C₁-C₆)-alkyl wherein the latter group is possibly substituted with one or more substitutes chosen independently from halogen atoms, -OR⁸ and -NR⁵R⁶, -S(O)_xR⁷ wherein x = 2; R⁴ means (C₁-C₆)-alkyl; R⁵ and R⁶ mean independently H, (C₁-C₆)-alkyl, or R⁵ and R⁶ in common with nitrogen atom to which they are bound can form 6-membered saturated heterocyclic ring comprising one atom chosen from -NR¹⁶; R⁷ means (C₁-C₆)-alkyl; R⁸ means H, (C₁-C₆)-alkyl; R¹⁶ means H, -COY-(C₁-C₄)-alkyl wherein Y means oxygen atom (O) and wherein alkyl group in the substitute group can be direct, branched or cyclic, and wherein heteroaryl means 5-6-membered heteroaromatic ring comprising from 1 to 3 heteroatoms chosen from nitrogen (N), oxygen (O) and sulfur (S) atoms, or means 6,6-condensed bicyclic aromatic ring system comprising one nitrogen atom. Compounds of the formula (I) can be used in production of a medicinal agent used in treatment of asthma and chronic obstructive disease.

EFFECT: valuable medicinal properties of compounds.

7 cl, 2 tbl, 59 ex