DERIVATIVES OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES AND RESPIRATORY WAYS DISEASES Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to derivatives of nitrogen-containing heterocyclic compounds of the general formula (I'):

wherein R represents the group:

m = 0-3; R¹ represents halogen atom, cyano-group and others; X represents oxygen or sulfur atom, or the group -CH₂ and others; Z¹ and Z² represents the group -CH₂ and others; Q represents oxygen or sulfur atom, or the group -CH₂ or -NH; R² represents substituted phenyl; n = 0-2; R³ represents (C₁-C₆)-alkyl, (C₁-C₆)-alkoxycarbonyl group and others; R⁴, R⁵, R⁶ and R⁷ represent hydrogen atom or (C₁-C₆)-alkyl and others; R⁸ represents hydrogen atom, (C₁-C₆)-alkyl. Compounds of the formula (I') possess of activity modulating activity of chemokine MIP-1α receptors and can be used in medicine in treatment of inflammatory diseases and respiratory ways diseases.

EFFECT: improved preparing method, improved methods for treatment, valuable medicinal properties of compounds and composition.

20 cl, 283 ex