THIENOPYRIMIDNEDIONES, METHODS FOR THEIR PREPARING (VARIANTS) AND PHARMACEUTICAL COMPOSITION Russian patent published in 2007 - IPC C07D495/04 A61K31/519 A61P37/06 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to compounds of the formula (1): wherein each R¹ and R² represents independently (C₁-C₆)-alkyl, (C₃-C₆)-alkenyl, (C₃-C₆)-cycloalkyl-(C₁-C₃)-alkyl or (C₃-C₆)-cycloalkyl wherein each of them can be substituted possibly with halogen atom in the amount from 1 to 3; R³ represents isoxyzolydine-2-ylcarbonyl or tetrahydroisoxazine-2-ylcarbonyl wherein each ring is substituted possibly with one hydroxy-group; Q represents -CO- or -C(R⁴)(R⁵)- (wherein R⁴ represents hydrogen atom or (C₁-C₄)-alkyl, and R⁵ represents hydrogen atom or hydroxy-group); Ar represents 5-10-membered aromatic ring system wherein up to 4 ring atoms can be represented by heteroatoms chosen independently from nitrogen, oxygen and sulfur atoms and wherein this ring system is substituted possibly with one or more substitute. Proposed compounds can be used for modulation of autoimmune disease. Also, invention describes methods for synthesis of compounds of the formula (1) and pharmaceutical composition based on compounds of the formula (1).

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.

14 cl, 44 ex