AGENT POSSESSING WITH VEIN-TONIC, ANTI-INFLAMMATORY AND CAPILLARY-PROTECTIVE EFFECT AND METHOD FOR ITS PREPARING Russian patent published in 2006 - IPC A61K36/49 A61P9/14 A61P7/02 A61P29/00 

FIELD: medicine, chemical-pharmaceutical industry.

SUBSTANCE: invention relates to an agent based on extractive substances from horse chestnut seeds (Fructus aesculi hippocastani) used as an agent in treatment of vein varicosity, thrombosis and post-traumatic edemas. Agent possessing vein-tonic, anti-inflammatory and capillary-protecting effects represents the horse chestnut seeds tincture (Fructus aesculi hippocastani) prepared by extraction of the raw with 35-45% ethyl alcohol in the ratio raw to extractant = 1:10 and containing saponins as measured for escein 0.2-3.0 wt.-% and horse chestnut extractive substances in the amount 1.0-5.0 wt.-% of the total tincture mass. Agent is designated for treatment of vein varicosity, thrombosis and post-traumatic edemas in the dose 15-20 drops, 3 times per a day, for 2-3 weeks. Method for preparing the agent possessing the vein-tonic, anti-inflammatory and capillary-protective effect involves extraction of horse chestnut seeds (Fructus aesculi hippocastani) with 35-45% ethyl alcohol in the ratio raw to extractant = 1:10. During this extraction process the raw is kept in extractant medium for swelling for 4-6 h, stirred and heated if necessary to temperature 40°C, not above, and the prepared extract is settled at temperature 4-8°C for 30 h, not less. The prepared horse chestnut tincture possesses the broad spectrum of therapeutic effect and improves blood rheological properties, shows tonic effect on vessels and optimizing effect of hemocirculation.

EFFECT: improved preparing method, valuable medicinal properties of agent.

3 cl, 11 tbl