ATORVASTATIN CALCIUM IN PHARMACEUTICAL FORMULATION, ITS COMPOSITION AND ATORVASTATIN CALCIUM-CONTAINING PHARMACEUTICAL PRESCRIPTION Russian patent published in 2007 - IPC A61K31/40 A61K9/48 A61K9/20 A61K9/16 A61P3/06

Abstract RU 2293555 C2

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to medicaments, namely, to a pharmaceutical composition used in treatment of hypercholesterolemia and hyperlipidemia. Pharmaceutical composition comprises micronized atorvastatin calcium and a substance for correcting pH value taken in the amount providing in dissolving this composition in 900 ml of aqueous medium with pH 3 increasing pH of indicated medium to a value as equal or exceeding pK_a + 1 for atorvastatin calcium. Also, invention relates to a method for preparing indicated pharmaceutical composition and its using in treatment of hypercholesterolemia and hyperlipidemia. Invention provides enhancing bioavailability of atorvastatin based on increasing its solubility in aqueous media.

EFFECT: improved and valuable pharmaceutical properties of medicament.

19 cl, 6 ex

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RU 2 293 555 C2

Authors

Kerk Janez

Mateja Salobir

Bavek Sasa

Dates

2007-02-20—Published

2002-03-13—Filed