PRODUCTS OF OXIDATIVE DECOMPOSITION OF ATORVASTATIN CALCIUM Russian patent published in 2011 - IPC C07D498/14 C07D493/04 C07D303/48 C07D207/40 A61K31/40 A61P9/00

Abstract RU 2412191 C2

FIELD: chemistry.

SUBSTANCE: invention relates to products of oxidative decomposition of atorvastatin calcium, specifically to 4-[6-(4-fluorophenyl)-6-hydroxy-1b-isopropyl-6a-phenyl-1a-phenylcarbamoylhexahydro-1,2-dioxa- 5a-azacyclopropa [a]inden-3-yl]-3-(R)-hydroxybutyric acid, phenylamide 4-(4-fluorophenyl)-2,4-dihydroxy-2-isopropyl-5-phenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxylic acid and 4-[1b-(4-fluorophenyl)-6-hydroxy-6-isopropyl-1a-phenyl-6a-phenylcarbamoylhexahydro-1,2-dioxa-5a-azacyclopropa [a]inden-3-yl]-3-(R)-hydroxybutyric acid. The invention also relates synthesis methods thereof, based on oxidation of an atorvastatin salt.

EFFECT: disclosed are products of oxidative decomposition of an atorvastatin salt, which can be used to identify impurities or a product of decomposition of an atorvastatin salt in accordance with approved analytical procedures.

15 cl, 5 tbl, 9 ex

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RU 2 412 191 C2

Authors

Granek Rok

Kots'An Darko

Bastarda Andrej

Kotsijan Andrej

Kratsun Mat'Az

Dates

2011-02-20—Published

2005-07-15—Filed