FIELD: biotechnologies.
SUBSTANCE: invention relates to biotechnology, specifically to method of treating metabolic disorder in individual by introducing agents, which modulate activity and microRNA expression, and can be used in medicine. Present invention provides method of treating disorders, such as obesity, diabetes or metabolic syndrome, in individual by adding inhibitor expression or activity of miR-378 and/or miR-378*.
EFFECT: invention enables effective therapy of wide range of metabolic disorders caused by violation of signal transmission using leptin.
9 cl, 19 dwg, 6 ex
| Title |
Year |
Author |
Number |
| DOUBLE TARGETING OF NUCLEOTIDE SEQUENCES MIR-208 AND MIR 499 IN TREATING CARDIAC DISEASES |
2010 |
- Olson Ehrik
- Ruidzh Eva Van
|
RU2515926C2 |
| OLIGONUCLEOTIDE SEQUENCES AIMED AT THE TRANSCRIPTION FACTOR TSC22D4, FOR TREATING INSULIN RESISTANCE |
2016 |
- Herzig, Stephan
- Berriel Diaz, Mauricio
- Schafmeier, Tobias
|
RU2723091C2 |
| VERSIONS OF RECOMBINANT AAV AND USE THEREOF |
2015 |
- Flotte, Terence
- Xie, Jun
- Gao, Guangping
|
RU2738421C2 |
| OLIGODENDROCYTE-SPECIFIC PROMOTOR, microRNA SPECIFIC TO PLP1 GENE, VECTOR CONTAINING SPECIFIED PROMOTOR AND/OR SPECIFIED microRNA, AND PHARMACEUTICAL COMPOSITION CONTAINING SPECIFIED VECTOR |
2019 |
- Inoue Ken
- Li Heng
- Okada Takashi
- Ohki Yu
- Koizumi Makoto
|
RU2788605C2 |
| AAV-BASED HUNTINGTON'S DISEASE TREATMENT |
2017 |
- Mueller, Christian
- Aronin, Neil
- Pfister, Edith, L.
|
RU2749971C2 |
| PHARMACEUTICAL COMPOSITIONS, KITS AND METHODS OF TREATING TUMORS |
2019 |
- Chen, Syaotsin
- Chzhou, Syujsha
- Rojzman, Bernard
- Chzhou, Grejs Goin
|
RU2810906C2 |
| MODULATION OF APOLIPOPROTEIN CIII (ApoCIII) EXPRESSION |
2012 |
|
RU2603076C9 |
| APPLICATION OF NKG2D INHIBITORS FOR TREATING CARDIOVASCULAR AND METABOLIC DISEASES SUCH AS TYPE 2 DIABETES |
2010 |
- Sjun Na
- Sja Mintsan'
- Rolet Dehvid Kh.
- Petersen Jakob Sten
- Bedvarsdouttir Toura Brin'Ja
|
RU2566264C2 |
| METHODS OF TREATING DIABETES AND/OR PROMOTING SURVIVAL OF PANCREATIC ISLETS AFTER TRANSPLANTATION |
2013 |
- Monteleone Dzhovanni
- Bukvald Peter
- Inverardi Luka
- Piledzhi Antonello
- Rikordi Kamillo
- Tomei Aliche
|
RU2667960C2 |
| MODULATING EXPRESSION OF ANGIOPOIETIN-LIKE PROTEIN 3 |
2014 |
- Freier Susan M.
- Graham Mark J.
- Crooke Rosanne M.
|
RU2706964C2 |
