HETEROCYCLIC INHIBITORS OF GLYCOGEN SYNTHASE-KINASE GSK-3 Russian patent published in 2007 - IPC C07D285/08 C07D417/12 A61K31/433 A61K31/4427 A61K31/4523 

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention relates to using compounds represented by the general formula (II): wherein R^a and R^b are chosen independently from hydrogen atom, alkyl, cycloalkyl, aryl (optionally substituted with a group chosen from alkyl, halogen atom and alkoxy-group), -(Z)_n-aryl (optionally substituted with a group chosen from alkyl, halogen atom and alkoxy-group), -(Z)_nC(O)OR³; Z is chosen independently from -C(R³)(R⁴)-; R³ and R⁴ are chosen independently from hydrogen atom, alkyl and 6-membered cycle with nitrogen atom as a heteroatom; n has values 0, 1 or 2; X and Y are chosen independently from =O, =S and =N(R³). These compounds are active component in preparing a pharmaceutical composition designated in treatment of diseases wherein glycogen synthase-kinase 3-beta (GSK-3) is involved. Also, invention relates to compounds represented by the general formula (II) wherein R^a is chosen from -CH₂Ph, -CH₂CO₂Et, 4-OMePh, 4-MePh and 4-BrPh; R^b is chosen from Me and -CH₂CO₂Et; X and Y represent =O. Also, invention relates to a pharmaceutical composition possessing GSK-3-inhibitory activity and containing compound of the general formula (II) as an active component. Invention provides using heterocyclic inhibitors of glycogen synthase-kinase-3β.

EFFECT: valuable biochemical and medicinal properties of inhibitors.

17 cl, 5 tbl, 5 ex