QUINAZOLINE DERIVATIVES Russian patent published in 2009 - IPC C07D239/84 C07D403/12 C07D407/12 A61K31/517 A61P25/28 A61P11/00 A61P11/06 A61P9/10 A61P9/00 

FIELD: chemistry, pharmacology.

SUBSTANCE: present invention relates to new compounds with formula (I), their esters, carbamates and pharmaceutically used salts, which can be used as inhibitors of p38 kinase, which means they can be used for curing diseases and conditions for which p38 is the mediator. In formula (I): Q represents -C(R¹R²R³); R¹ is chosen from hydrogen, C₁-C₈ alkyl, hydroxyC₁-C₈alkyl, and C₁-C₈alkoxy C₁-C₈alkyl; R² and R³ are chosen: (i) independently from: (a) hydrogen, under the condition that, if R¹ represents hydrogen, then only one of R² and R³ can be chosen from hydrogen; (b) C₁-C₈alkyl; C₁-C₈alkyl, substituted with one or two radicals halogen, -OR⁸, -S(O)_pR¹⁰;(c) -OR⁸; or (ii) R² and R³ together with the carbon atom to which they are bonded, form optionally substituted C₃-C₇cycloalkyl or substituted heterocyclic ring system; R⁴ and R⁵ are independently chosen from halogen; R⁸ and R⁹ are independently chosen from hydrogen, C₁-C₈alkyl; R¹⁰ represents C₁-C₈alkyl; m equals 0, n equals 0; and p equals 2; where the term "substituted cycloalkyl" stands for a cycloalkyl group, containing one or two substitutes, which are independently chosen from a group, consisting of -Y-OR^s, -Y-S(O)_0-2R^S, C(=O)OR^s, where Y is absent; R^s is independently chosen from hydrogen, C₁-C₈alkyl, except when the said substitute represents -Y-S(O)_1-2R^s, then R^S represents hydrogen; the term "heterocyclic ring system" stands for a saturated non-aromatic monocyclic fragment, consisting of 5 to 6 atoms, which are part of the ring system, from which one atom, which is part of the ring system, is a heteroatom, chosen from N, O, and the rest of the atoms in the ring system are carbon atoms; the term "substituted heterocyclic ring system" stands for a heterocyclic fragment mentioned above, containing one substitute, chosen from the group, -Y-R^s, -Y-OR^s, -Y-C(O)₂R^s, -Y-S(O)_0-2R^s, where Y is absent or represents a C₁-C₄alkylene group, R^s represents the same as was defined above for the substituted cycloalkyl group.

EFFECT: used for treating diseases and conditions.

13 cl, 2 dwg, 5 tbl, 17 ex