PYRAZOLE DERIVATIVES APPLICABLE AS PROTEIN KINASE INHIBITORS Russian patent published in 2009 - IPC C07D403/12 A61K31/506 A61P35/00 A61P3/10 A61P19/10 A61P25/18 A61P25/28

Abstract RU 2355688 C2

FIELD: chemistry.

SUBSTANCE: invention concerns novel pyrazole derivatives of the formula (IIIa) , where R¹ is T-(ring D), where ring D is naphthyl or phenyl optionally substituted by -R⁵; R^x, R^y, R², R^2' and R⁵ are as defined in the claim; and pharmaceutical composition containing claimed compounds. Compounds inhibit protein kinases such as Aurora-2, GSK-3 or Src and can be applied in treatment methods for diseases mediated by the indicated protein kinases, such as cancer, diabetes and Alzheimer's disease.

EFFECT: compounds also applicable in methods of hyperphosphorylated protein Tau products inhibition and β-catenin phosphorylation inhibition.

24 cl, 12 tbl, 292 ex

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RU 2 355 688 C2

Authors

Bebbington Dehvid

Sharr'Er Zhan-Damien

Golek Dzhulian

Miller Ehndrju

Negtel Ronal'D

Dates

2009-05-20—Published

2001-12-19—Filed