AZULENE DERIVATIVE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF DIABETES MELLITUS Russian patent published in 2007 - IPC C07D309/12 A61K31/35 A61P3/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to an azulene derivative of the formula (I): or its salt wherein each radical among R¹-R⁴ represents hydrogen atom, (lower alkylene)-O-(lower alkyl), -C(=O)-(optionally substituted lower alkyl) or (optionally substituted lower alkylene)-(optionally substituted aryl); each radical among R⁵-R¹² represents hydrogen atom, optionally substituted lower alkyl, halogen atom, (alkylene)-O-optionally substituted lower alkyl), -O-(optionally substituted lower alkylene)-(optionally substituted aryl), -COOH or -C(=O)-O-(optionally substituted lower alkyl); A represents a bond or optionally substituted lower alkylene wherein -A- can be bound at any position 1-8 of azulene cycle, and any two groups among R⁵, R⁶ and R⁷ can form benzene cycle in common with adjacent carbon atoms. Also, invention relates to a pharmaceutical composition based on these compounds and representing inhibitor of Na⁺-glucose co-transporter, and to a method for treatment of diabetes mellitus of type 1 (insulin dependent) and type 2 (non-insulin dependent).

EFFECT: valuable medicinal properties of compounds and pharmaceutical composition, improved method of diabetes mellitus treatment.

7 cl, 25 tbl, 75 ex