C-PHENYL GLYCITOL COMPOUND FOR TREATING DIABETES Russian patent published in 2011 - IPC C07D309/10 C07D405/12 C07D405/10 C07D405/14 A61K31/351 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel C-phenyl glycitol compound which serves as a preventive or therapeutic agent for sugar diabetes by inhibiting SGLT1 activity, as well as SGLT2 activity; demonstrating inhibiting effect on glucose absorption, and also acts on release of glucose with urine. The C-phenyl glycitol compound has formula (I) given below, or pharmaceutically acceptable salt or hydrate thereof, where R¹ and R² are identical or different and denote a hydrogen atom, a hydroxyl group, a C_1-6 alkyl group, a C_1-6 alkoxy group or a halogen atom, R³ is a hydrogen atom, a C_1-6 alkyl group or a C_1-6 alkoxy group, Y is a C_1-6 alkylene group, -O-(CH₂)n- (n is a whole number which assumes values from 1 to 4), provided that when Z denotes -NHC(= NH)NH₂ or -NHCON(R^B)R^c, n not equal to 1, Z is -CONHR^A, -NHC(=NH)NH₂ or -NHCON(R^B)R^c, or The invention also relates to a pharmaceutical composition based on compounds of formula I.

EFFECT: high efficiency of the compounds.

19 cl, 8 tbl