C-PHENYL-1-THIOGLUCITOLS Russian patent published in 2011 - IPC C07D335/02 A61K31/382 A61P3/10 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention relates to C-phenyl-1-thioglucitols of formula (I), [formula I] , where X is a hydrogen atom or a C_1-6alkyl group, Y is a C_1-6alkylene group or -O-(CH₂)_n- (where n equals a integer from 1 to 5), and Z is -CONHR^A or -NHCONHR^B (provided that when Z is -NHCONHR^B, n is not equal to 1), where R^A is a C_1-6alkyl group substituted with 1-3 substitutes selected from a group consisting of a hydroxyl group and -CONH₂, and R^B denotes a hydrogen atom or a C_1-6alkyl group substituted with 1-3 substitutes selected from a group consisting of a hydroxyl group and -CONH₂, and pharmaceutically acceptable salts thereof or hydrates thereof. The invention also relates to a sodium-dependent glucose transporter 1 (SGLT1) activity inhibitor, a sodium-dependent glucose transporter 1 (SGLT1) and sodium-dependent glucose transporter 2 (SGLT2) activity inhibitor, as well as a prophylactic or therapeutic agent against diabetes.

EFFECT: obtaining novel biologically active compounds which are sodium-dependent glucose transporter 1 and sodium-dependent glucose transporter 2 activity inhibitors.

5 cl, 11 ex, 4 tbl