5'-BROMOLAPPACONITINE HYDROBROMIDE POSSESSING ANTI-ARRHYTHMIC ACTIVITY Russian patent published in 2007 - IPC C07D471/08 A61K31/46 

Abstract RU 2295524 C1

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to a novel chemical compound, namely, to biologically active compound of the formula (I): possessing anti-arrhythmic activity and representing 5'-bromolappaconitine hydrobromide. Toxicity of this compound is by 4.8-fold less toxic as compared with analog used in medicinal practice and representing lappaconitine hydrobromide. Proposed compound possesses the expressed anti-arrhythmic activity in models with calcium chloride and adrenaline arrhythmia and provides the complete blocking both types of arrhythmia after administration of the dose that is 10-fold less of the therapeutic dose of lappaconitine hydrobromide.

EFFECT: improved and valuable medicinal properties of compound.

2 cl, 2 tbl, 4 ex

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Authors

Osadchij Stanislav Aleksandrovich

Shul'Ts Ehl'Vira Ehduardovna

Martynov Aleksej Anatol'Evich

Bryzgalov Arkadij Olegovich

Tolstikova Tat'Jana Genrikhovna

Dolgikh Margarita Petrovna

Sorokina Irina Vasil'Evna

Tolstikov Genrikh Aleksandrovich

Dates

2007-03-20Published

2005-08-29Filed