RAPID DEGRADATION DOSAGE FORM RELEASING ACTIVE COMPONENTS INTO ORAL CAVITY OR BODY CAVITIES Russian patent published in 2007 - IPC A61K9/70 A61K9/00 A61K9/44 A61K9/12 

FIELD: medicine.

SUBSTANCE: preparation is characterized by rapidly degrading or water-soluble plate in the environment, mainly consisting of one or several polymers soluble in water, and at least one active ingredient. The dosage form matrix is hardened foam in which empty spaces or cavities are available as a result of foaming soluble polymers in water containing foam-stabilizing substance differing from the active component. The cavities are filled with gas, gas mixtures or, preferably, with air. Dosage form thickness is 50 μm-5 mm large. Dosage form surface is rough or irregular, preferably made corrugated or zoned. Method involves producing plate-shaped dosage forms, distinguished by water-soluble polymers solution-, dispersion medium - or melt-foaming stages realization. The foaming stage is carried out as, for example, foaming film-forming polymer solution or dispersion medium by introducing gas or gas mixtures into it after having preliminarily added foam-stabilizing substances or by carrying out dissolved gas decompression, when needed, after adding foam-stabilizing substances, or by adding hydrophobic solvent which does not mix up with solvent, used for preparing water-soluble polymer solution or a dispersion medium with emulsion being produced, that contains hydrophobic solvent as finely dispersed drops. The solvent is the removed producing in this way foamed matrix structure, or by adding fillers or filler combinations, capable of gassing, or foaming water-soluble polymer melt by introducing gas or gas mixtures into it, or by receiving gas in chemical way, or by decompressing dissolved gas if needed, after having preliminarily added foam-stabilizing substances. A plate for introducing drugs is described with active ingredient selected from group composed of nicotine and nicotine bitartrate.

EFFECT: enhanced effectiveness of treatment; wide range of functional applications.

9 cl