DERIVATIVES OF 8-METHOXY-[1,2,4]TRIAZOLO[1,5-a]PYRIDINE AND PHARMACEUTICAL PREPARATION BASED ON THEREOF Russian patent published in 2007 - IPC C07D471/04 A61K31/41 A61P25/18 A61P25/24 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes novel derivatives of 8-methoxy[1,2,4]triazolo[1,5-a]pyridine of the general formula (I): wherein R¹ means unsubstituted phenyl or phenyl substituted with one substitute chosen from group including halogen atom, trifluoromethyl, (lower)-alkyl, (lower)-alkoxy-, acetylamino-group, acetyl, (lower)-alkenyl, -C(O)O-(lower)-alkyl or thio(lower)-alkyl, or thiophenyl possibly substituted with halogen atom, or indolyl; R² means unsubstituted phenyl or phenyl substituted with a single substitute chosen from group including halogen atom, (lower)-alkyl, halogen-(lower)-alkyl or (lower)-alkoxy-group, or thiophenyl possibly substituted with (lower)-alkyl, their pharmaceutically acceptable salts, and pharmaceutical preparation based on thereof. Novel compounds possess antagonistic effect on adenosine A_2A-receptors and can be used in medicine for stimulation of the central nervous system activity and as enhancers of cognitive ability.

EFFECT: valuable medicinal properties of compounds and pharmaceutical preparation.

10 cl, 1 tbl, 1 ex