FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel compounds chosen from the following substances: Ph-(3-Cl)-(5-OCHF2)-(R)-CH(OH)C(O)-Aze-Pab(OMe); Ph-(3-Cl)-(5-OCHF2)-(R)-CH(OH)C(O)-Aze-Pab(OH), and Ph-(3-Cl)-(5-OCHF2)-(R)-CH(OH)C(O)-Aze-Pab or their pharmaceutically acceptable salts. Proposed compounds inhibit thrombin and can be used in pharmaceutical composition for treatment state wherein thrombin inhibition is required.
EFFECT: valuable medicinal properties of compounds.
16 cl, 49 ex
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2003 |
- Abrakhmsen Alami Susanna
- Ingkhardt Tord
- Magnusson Anders
- Sigfridsson Karl-Gustaf
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RU2351314C2 |
| ALMOND ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITOR |
2002 |
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RU2341516C2 |
| TIME-RELEASE PHARMACEUTICAL COMPOSITION AND USE THEREOF |
2003 |
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|
RU2474416C2 |
| PHARMACEUTICAL COMPOSITION |
2002 |
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|
RU2323006C2 |
| PHARMACEUTICAL PREPARATION WITH MODIFIED ELUTION |
2003 |
- Magnusson Anders
- Tune Mikaehl'
|
RU2352323C2 |
| THROMBIN INHIBITORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF TREATMENT, METHOD OF THEIR SYNTHESIS (VERSIONS) AND PROTECTED DERIVATIVE |
1996 |
- Gustafsson David
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RU2176645C2 |
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1994 |
- Karl Tomas Antonsson
- Rut Ehl'Vju Bjulund
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RU2142469C1 |
| PRODRUGS OF THROMBIN INHIBITORS |
1996 |
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RU2176644C2 |
| THROMBIN INHIBITOR-CONTAINING AQUEOUS SOLUTION FOR NONPARENTERAL ADMINISTRATION SHOWING STABILITY AT STORAGE |
1995 |
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RU2164803C2 |
| MONOCYCLIC L-NUCLEOSIDES, THEIR ANALOGUES AND USING |
1997 |
- Ramasejmi Kandasejmi
- Tehm Robert
- Ehverett Devron
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RU2188828C2 |
