FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparation for nonparenteral administration. Preparation can be used for treatment of patients with diseases accompanying with hypercoagulation. An aqueous solution of the preparation has pH 1.0-2.5 and it contains thrombin inhibitor of the formula: HOOC-
-Y where Y means (R)-Cha- -Pic-Nag or (R)-Cgl-Aze-Pab as salt or free base. Preferable concentration of inhibitor is 0.001-300 mg/ml. Invention provides to obtain the preparation that is stable at storage for two years, not less, at the room temperature. After this time the residual activity of preparation is 95%, not less. EFFECT: improved properties of preparation. 8 cl, 13 tbl, 8 ex
| Title |
Year |
Author |
Number |
| PEPTIDE DERIVATIVES, THEIR STEREOISOMERS OR PHYSIOLOGICALLY ACCEPTABLE SALTS SHOWING ANTITHROMBOSIS, ANTICOAGULATING OR ANTI-INFLAMMATORY ACTIVITY, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF SUPPRESSION OF THROMBIN ACTIVITY, METHOD OF INHIBITION OF KININOGENASES ACTIVITY, USE OF COMPOUNDS AS PARENT SUBSTANCES FOR SYNTHESIS OF THROMBIN INHIBITOR |
1994 |
- Karl Tomas Antonsson
- Rut Ehl'Vju Bjulund
- Nil'S David Gustafsson
- Nil'S Olov Ingemar Nil'Sson
|
RU2142469C1 |
| THROMBIN INHIBITORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF TREATMENT, METHOD OF THEIR SYNTHESIS (VERSIONS) AND PROTECTED DERIVATIVE |
1996 |
- Gustafsson David
- Njustrem Jan-Ehrik
|
RU2176645C2 |
| PRODRUGS OF THROMBIN INHIBITORS |
1996 |
- Antonsson Tomas
- Gustafsson David
- Khoffmann Kurt-Jurgen
- Njustrem Jan-Ehrik
- Serensen Khenrik
- Sellen Mikaehl'
|
RU2176644C2 |
| NOVEL DERIVATIVES OF MANDELIC ACID AND THEIR USING AS THROMBIN INHIBITORS |
2001 |
- Ingkhardt Tord
- Jokhansson Anders
- Svensson Arne
|
RU2300521C2 |
| PHARMACEUTICAL PREPARATION WITH IMMEDIATE RELEASE |
2003 |
- Abrakhmsen Alami Susanna
- Ingkhardt Tord
- Magnusson Anders
- Sigfridsson Karl-Gustaf
- Tune Mikaehl'
|
RU2351314C2 |
| ALMOND ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITOR |
2002 |
- Ingkhardt Tor
- Jokhansson Anders
- Svensson Arne
|
RU2341516C2 |
| 4-AMINO-3-ACYLQUINOLINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL AGENT BASED THEREOF, METHOD OF PREPARATION OF PHARMACEUTICAL AGENT, AND INTERMEDIATE COMPOUND |
1994 |
|
RU2142454C1 |
| PHARMACEUTIC PREPARATION CONTAINING CARBOXYPEPTIDASE U INHIBITOR AND THAT OF THROMBIN |
2000 |
- Abrakhamsson Tommi
- Nerme Viveka
- Polla Magnus
|
RU2242992C2 |
| PHARMACEUTICAL PREPARATION WITH MODIFIED ELUTION |
2003 |
- Magnusson Anders
- Tune Mikaehl'
|
RU2352323C2 |
| PHARMACEUTICAL COMPOSITION |
2002 |
- Gaik-Lim Kkhoo Sintija
- Gustafsson Khelena
|
RU2323006C2 |
