FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparation for nonparenteral administration. Preparation can be used for treatment of patients with diseases accompanying with hypercoagulation. An aqueous solution of the preparation has pH 1.0-2.5 and it contains thrombin inhibitor of the formula: HOOC-
-Y where Y means (R)-Cha- -Pic-Nag or (R)-Cgl-Aze-Pab as salt or free base. Preferable concentration of inhibitor is 0.001-300 mg/ml. Invention provides to obtain the preparation that is stable at storage for two years, not less, at the room temperature. After this time the residual activity of preparation is 95%, not less. EFFECT: improved properties of preparation. 8 cl, 13 tbl, 8 ex
Title |
Year |
Author |
Number |
PEPTIDE DERIVATIVES, THEIR STEREOISOMERS OR PHYSIOLOGICALLY ACCEPTABLE SALTS SHOWING ANTITHROMBOSIS, ANTICOAGULATING OR ANTI-INFLAMMATORY ACTIVITY, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF SUPPRESSION OF THROMBIN ACTIVITY, METHOD OF INHIBITION OF KININOGENASES ACTIVITY, USE OF COMPOUNDS AS PARENT SUBSTANCES FOR SYNTHESIS OF THROMBIN INHIBITOR |
1994 |
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|
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|
RU2176645C2 |
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1996 |
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|
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|
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|
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