METHOD FOR PREPARING DERIVATIVES OF 2-(6-SUBSTITUTED-1,3-DIOXANE-4-YL)-ACETIC ACID Russian patent published in 2007 - IPC C07D319/06 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of derivative of 2-(6-substituted-1,3-dioxane-4-yl)-acetic acid of the formula (1): wherein each R¹, R² and R³ represents independently (C₁-C₄)-alkyl group, or wherein R¹ and R² in common with carbon atom to which they are bound form 5- or 6-membered cycloalkyl, and wherein Y represents R^A-CO- wherein R^A is chosen from alkyl group or aryl with 1-12 carbon atoms, its corresponding derivative of 2-(6-substituted-4-yl)-acetic acid of the formula (2): wherein R¹, R² and R³ are given above, and wherein X represents halogen atom. Method is carried out in the presence of an interphase catalyst and oxidizing agent and involves using quaternary phosphonium ion of the formula (3): wherein each R⁴, R⁵, R⁶ and R⁷ represents alkyl, cycloalkyl, aralkyl or aryl with 1-12 carbon atoms as an interphase catalyst and ion of the formula (4): OY^- (4) wherein Y is given above is used as an oxidizing agent and wherein R^A, R⁴, R⁵, R⁶ and R⁷ in case if R⁴, R⁵, R⁶ and R⁷ represent aryl or aralkyl can be substituted with substitutes chosen from group consisting of halogen atoms, alkoxy-group with 1-5 carbon atoms, alkyl with 1-6 carbon atoms or nitro-group.

EFFECT: improved method of synthesis.

8 cl, 1 dwg, 3 ex